The formation,transformation and preservation of Dongsheng sandstonetype uranium deposit is the combined action of the organic and inorganic fluid,in these processes there are a number of recognizable epigenetic alterated signs.Researches on the characteristics of stable isotopes in these fluid products could date from types,characteristics and nature of fluid,which provides a theoretical basis for deposit causes and mineral prospecting.This research main selects carbon and oxygen isotopes in calcite in calcified wood and sulfur isotopes in pyrite in sandstone.The carbon and oxygen isotopes analysis showes that the formation of lenticular carbonate and calcified wood and carbon source are relate to the fluid action of organic matter;Sulfur isotope analysis indicates that sulfur source has the characteristic between the biological bacteria and coal.According to the former researches on the carbonate hydrogen and oxygen isotope and fluid physical-chemical parameters,the paper presents an opinion that the formation of Dongsheng deposit is the result of combined fluid action by atmospheric precipitation-dissipation hydrocarbon-coal organic acid-low-temperature hydrothermal.