Comprehensively considering depththickness ratio in the role of the earthquake on the in-fluence of multilayer steel plate shear wall,the stress and displacement of the steel plate shear wallwere analyzed by using the finite element method to establish the four layer single span steel plateshear wall and four layer three span steel framesteel plate shear wall lateral force resisting analysiscalculation model.The result shows that the steel structure of the depththickness ratio influence onearthquake resistance;the four layer three span steel framesteel plate shear wall system is betterthan the four layer single span steel plate shear wall system seismic performance;it is suggested thatunder normal circumstances,the muftilayer single span steel plate shear wall thick steel plate isdepththickness ratio values for =200300,multilayer high mufti span steel plate shear walplate depththickness ratio values for=200400.