Based on a pre-stressed concrete hollow slab bridge which located in Shandong province, the engineering security of truck weight limits model on highway bridges was verified systematically. Firstly, the bridge of carrying capacity is checked to verify the bridge weather meet the design requirements by according to the bridge design data and the design of truck weight of 2004 code .Then, the load effect and the deflection of mid-span of bridge in different typical truck of weight limits were calculated by according to the design of the truck lateral load patterns aiming at different safety classes ,respectively. And the data were compared with the design of truck weight to verify the engineering security of truck weight limits on highway bridges. The results indicate that, when the safety class of bridge truck weight limit were class one and class two, the corresponding typical truck of weight limits can satisfy the carrying capacity requirements of class one, class two and class three. when the safety class of bridge truck weight limit were class three, the corresponding typical truck of weight limits can satisfy the carrying capacity of normal section requirements of class one, class two and class three, but hardly satisfy the carrying capacity of cross section requirements of class one.