In order to study the vulnerability of the frame structure based on the inelastic displacement response spectrum, six different periods of reinforced concrete frame model are established by finite element software. Then propose four limit states quantization index of evaluating frame structure damage. The fragility curves of frame structure were obtained by IDA analysis method; Seismic hazard curves were obtained by using the response spectrum method, and then get the frame structure seismic collapse safety reserve coefficient. The results provide a reference for the future evaluation of the vulnerability of the framework structure.