Experimental study on the disintegration characteristics of sandstone and mudstone is investigated based on the diversion project of water from Yangtze to Huaihe River. The disintegration characteristics of soft rock with different weathering degree under drying and wetting cycles are studied by drying-immersion static rock slaking test. At the same time, the rock slake-durability tests and point load strength test are carried out to reveal the correlation law between disintegration and strength, the loss of moisture. The results show that the effect of drying and wetting cycles and weathering could weaken the rock slake-durability; and the rock slake-durability index increases approximately linear with the point load strength and decreases approximately linear with the loss of moisture of the rock. The slakedurability of rocks is related to rock structure types.