In order to reduce the monitoring section settings without affecting the water pollution control,the SPSS clustering analysis is used in this paper. This paper is based on monitoring data of eight monitoring sections of Fuyang River and the spss cluster analysis is used to cluster five water quality indexes,such as COD,ammonia nitrogen and so on. This paper also makes a brief analysis of water quality variation on some monitoring sections. The results show that eight monitoring sections are divided into three categories. Thereby,this paper determines the affinities between the monitoring sections. It implied that clustering analysis can play a very good role in categorization analysis of multiple monitoring sections and water pollution control of Fuyang River.