Abstract:This paper discussed the transversely isotropy and heterogeneity of the slope and analyzed the calculation method considering transverse isotropy and heterogeneity. The anti-skid moment calculation formula of the soil and the anti-slide pile was developed by the limit equilibrium method. Calculation method of slope reinforced by anti-slide piles considering soil strength transversely isotropic and heterogeneous was developed by modifying the safety factor calculation for the anti-skid moment calculation formula of the soil and the anti-slide pile. The situ case showed that when the horizontal cohesion was assumed to be a constant,the relative error of the safety factor of the transversely isotropic slope was less than that without considering the transversely isotropic nature of the soil strength,which meant that it is necessary to consider the transversely isotropic nature of the soil strength in the anti-slide pile reinforced slope engineering.