In the light of the problem of gas extraction and disaster control for coal mining face with high gas and low permeability, No.15311 fully-mechanized face of Tucheng Mine was considered as an object of study in this paper. Firstly, the source of gas emission was preliminarily analyzed, the different-source prediction method was applied to predict the gas emission. Secondly, several methods of gas extraction, such as in-seam boreholes in mining seam, boreholes through mining seam in bed plate tunnel, boreholes in the high level gateway, and the pipeline buried in the goaf, was used to put forward the 3D prevention and control technology for gas combining with the ventilation in coal mining face. Basic on it, the spillover gas was intercepted and pulled out by drilling construction in the roadway floor, and the effect of extraction is also investigated. The filed practice indicated that:the source of gas emission in No.15311 fully-mechanized face is mainly form the coal seam and the lower adjacent layer, total gas extraction is 45.4 m³/t, gas extraction rate is 85.33%, the concentration of gas has not exceeded 1% in return air, this effectively control coal mining face of gas emission source.