The rocks of TBM hole excavated material were used as the source of coarse aggregate of concrete. Two kinds of aggregate gradations were designed and five water-cement ratios of 0.55, 0.60, 0.65, 0.70 and 0.75 were used to study the compression strength of TBM concrete. The experimental results show that the compression strength of TBM concrete is less than that of ordinary crashed stone concrete at the same water-cement ratio, And with the increase of water-binder ratio, the compression strength of TBM concrete decreases more than that of ordinary concrete. In addition, in the range of water-cement ratio of 0.55 to 0.75, the relationship between the compression strength of TBM concrete and the water-cement ratio is a linear function with negative correlation. Besides, the rational use of Talbot formula is instructive to aggregate gradation of TBM concrete.