The silo-frame structure is characterized by high center of gravity, high loading, poor overall stability and local stability, which is easily damaged under earthquake. In order to mitigate the damage of the silo-frame structure under earthquake, based on the project of degasification and storage silo-frame structure of a petrochemical company, ANSYS software was used to establish the finite element models of single silo-frame structure and seismic isolation structure respectively, and the dynamic response of the original structure and seismic isolation structure was analyzed under two working conditions of empty and full silo. The data of stress, displacement and strain of the silo-frame isolated structure model under different working conditions were analyzed by using the vibration decomposition reaction spectrum method and time course analysis method. The data analysis shows that the use of vibration isolation bearings can significantly improve the seismic capacity of the structure and the time course analysis is more accurate than the vibro-decomposition reaction spectrum method. A few suggestions has been put forward for the design of future silo-frame structures.