In order to study the influence of CaCl₂ solution injection in different grouting sequence on the electrochemical reinforcement effect during anode and intermediate holes grouting, three groups of experiments were carried out, which were injected at the same time(S1), injected at an interval of 5 h(S2) and injected at an interval of 12.5 h(S3).By monitoring the drainage, current, soil settlement and penetration resistance of treated soil, the three groups of experiments were compared and analyzed. The results show that the combination of anode and intermediate holes grouting can promote the uniformity of treatment effect in the upper and lower half of the area, delaying the grouting time of the intermediate hole is beneficial to increase the total drainage. Grouting in the intermediate hole at different times promotes the consolidation settlement in the lower half of the area. In the three groups of tests, the final settlement at each point of S2 test is more uniform than that of S1 and S3 tests. After the experiment, the distribution range of penetration resistance in the upper and lower halves of the S2 and S3 groups is significantly larger than that of the S1 group, grouting in the intermediate hole earlier is not conducive to the reinforcement of the upper and lower half areas.