Focusing on the stability of the pile-slab structure, FLAC^3D simulation calculation software was used to study the seismic response of pile-slab wall in the deposit slope under different parameters by numerical analysis method, and the seismic effect of pile-slab structure was evaluated. The results show that the dynamic characteristics of the structure have a significant effect on the seismic effect, and the seismic wave near the natural frequency of the slope has a greater damage to the slope; in the seismic intensity areas of VⅡ and VⅢ, the sheet pile wall can effectively play an anti-seismic role, but in the seismic intensity area of IX, the displacement of the pile exceeds 10 % of the pile length, which cannot meet the needs of anti-sliding; the difference of pile spacing directly affects the distribution of soil pressure on pile and in a certain range, the soil pressure on pile back will decrease with the decrease of pile spacing; influence of parameters of sliding body on back earth pressure of anti-slide pile is less than pile displacement; various factors should be considered in the design of pile - slab structure to avoid waste of resources.