In order to accurately grasp the current situation of agricultural non-point source pollution in Handan of Haihe River Basin, this paper used the output coefficient method, equal standard pollution load method, and ArcGIS technology and system clustering method to estimate and analyze the pollution of counties of Handan city. In 2019, the chemical oxygen demand (COD), total nitrogen (TN), total phosphorus (TP) and ammonia nitrogen (NH₃-N) of pollutants in Handan city were 58396t, 6046t, 1348t and 4669t respectively, and the COD pollutants were the largest. The equivalent pollution load evaluation showed that TN and TP were the main pollutants, and the load ratios were 29.67% and 33.08%, respectively. Livestock and poultry breeding source and fertilizer loss source were the main pollution sources, and the load ratios were 41.97% and 38.72%, respectively. The fertilizer loss pollution was the main contributor to TP while the livestock and poultry breeding pollution was the main contributor to NH₃-N, and the contribution rates of each pollution source to COD and TN were relatively average. The agricultural non-point source pollution in Handan city was divided into six pollution types, the strict supervision area was determined, and the corresponding treatment measures were put forward so as to provide a reference and guidance for comprehensive treatment in the future.