The seismic inversion and single seismic attribute reservoir prediction of Xishanyao Formation in Hu218 of Santanghu Oilfield have poor results, and the understanding of sand body distribution patterns is unclear, which restricts the development effect of the oilfield. In response to the current situation of reservoir prediction in the research area, a three-step strategy was adopted to achieve effective prediction of delta reservoirs. Firstly, the relationship between seismic attributes and sand to ground ratio was analyzed, and seismic attributes with high correlation were selected. The sand to ground ratio distribution map was obtained through multi-attribute fitting, clarifying the macroscopic boundary characteristics of sedimentary facies; Secondly, analyze the relationship between sedimentary microfacies and seismic waveforms in each well, and establish six typical seismic facies identification charts; Finally, a distribution map of sedimentary microfacies in the study area is drawn by combining macroscopic boundary characteristics with seismic identification diagrams of sedimentary microfacies. The results indicate that the combination of seismic multi-attribute fitting and seismic analysis can reflect the distribution characteristics of sedimentary microfacies from both macro and micro levels.