This paper takes buried X80 pipeline as the research object, and discusses the influence law of incidence angle, corrosion parameters and insulation layer on seismic response of pipeline corrosion area. Under the excitation of P wave and SV wave, the stress in the center of the pipeline corrosion area reaches the maximum value of 556.7 and 559.7 MPa and increases by 26.1% and 28.0% when the incidence angles θ_v and θ_h are 60° and 45° and 30° and 45°, respectively, compared to that of 441.3 and 437.0 MPa under the vertical incidence. When the incidence angle was the maximum response angle, the influence ratio of corrosion depth, length and width on corrosion pipe stress under P wave and SV wave was 58.0% and 51.9%, 22.8% and 27.1%, and 19.2% and 21.0%, respectively. The increase of the thickness of the pipeline insulation layer can effectively reduce the maximum stress in the corrosion zone of the pipeline under earthquake. Therefore, in the seismic design and maintenance of pipelines, we should pay attention to the incidence angle of seismic waves and corrosion depth, and consider the seismic isolation effect of insulation layer.