In order to estimate the heat extraction potential of the U-shaped underground heat exchange system in the middle and deep layers, a simulation verification was carried out using a U-shaped buried pipe heat exchange model programming in the middle and deep layers. Taking into account six factors including the soil thermal conductivity, vertical pipe length, ground temperature gradient, horizontal pipe length, soil density, and constant temperature layer temperature, a uniform experimental design method was used to design a simulation test plan. Multiple linear regression method was used to analyze the relationship between the six factors and the heat extraction, and a prediction equation for the heat extraction was established. The results shows that the maximum stable heat transfer of the U-shaped bu-ried pipe heat exchanger in the middle and deep layers can be predicted using five factors including the soil thermal conductivity, vertical pipe length, ground temperature gradient, horizontal pipe length, and constant temperature layer temperature. The maximum stable heat transfer prediction value is obtained. The average error compared to the simulated value is 6.76%, and the maximum relative error is -9.88%.