Aiming at the influence of different solvent environments on Fe-MnO_x catalysts during the preparation process, Fe-MnO_x catalysts were prepared by a one-step co-precipitation method. The inf-luence of different solvent environments on catalyst activity during the synthesis of the catalyst was investigated. It was found that the catalyst prepared by glycerol as a solvent environment had the best low-temperature activity and sulfur resistance. Through a series of characterization analyses, it was found that the catalyst prepared in a glycerol environment has regular particle morphology and particle size, the largest specific surface area, abundant and evenly distributed pore structure, and the highest contents of Mn⁴⁺, Fe³⁺ and Oα. Therefore, under the condition of 50 ℃ and GHSV=30 000/h, the catalyst can be used to improve the quality of the catalyst. It shows more than 80% NO_<em>x removal rate and better sulfur resistance.