In order to analyze the correlation between asphalt and asphalt mixture indexes before and after aging, this paper carried out a series of indoor experimental tests including:asphalt penetration, ductility and softening point tests at different aging stages, and the semi-circular bending tensile test of AC-13 asphalt mixture in different aging periods under the condition of medium and low temperature to analyze the evolution laws of the mechanical strength, the elastic modulus and the fracture energy of the mixture; The correlation regression analysis is carried out between the three indexes of asphalt before and after aging and the mechanical indexes of asphalt mixture. The test results show that the initial stage of aging has a great influence on the strength and elastic modulus of the mixture, and the aging is more sensitive to the elastic modulus; The mixture has an obvious effect on the low-temperature fracture energy, and the medium temperature fracture energy is significantly higher than the low-temperature fracture energy. The strength and the elastic modulus of mixture before and after aging have high a linear correlation with the three indexes of asphalt. Penetration can predict the mechanical properties of mixture at medium and low temperature.