5一Fluorouracial iS a kind of effective anticancer drug used in clinic and to conl∞I tunlor cells obviously．But it also has stronge toxic side—effect．Normal cells will be killed seriously．Therefore，syn— thesizing highly effective and lowly toxic 5——fluoroumeial ramifications is considered widely by scientists． In this paper，anticancer activity of 5一fluomuracial ramifications is reviewed．