The currently study on two-tower structure with enlarged base only focused on the seismic behavior and the consideration of the temperature stress was rarely taken into account. To address the above problem, the seismic behavior of structure under the combined effect of temperature and seismic action was discussed under response spectrum analysis by using the finite element analysis software SAP2000. It can be concluded that the temperature effect on the seismic performance is not huge, but it causes stress concentration in the local components of twin-towers structure, and the distribution of internal forces are changed; shear capacity of the wall are weakened, resulting in the bigger seismic shear force on the bottom column of frame, it should be pay more attention in the seismic design.