In this paper,based on the measured data from section EX-5 of Vietnam Hanoi - Hai Phong expressway and by using ABAQUS software,the soil consolidation settlement process was simulated by the method of drain with pre-loading.We made the genetic algorithm combine with ABAQUS software and wrote genetic algorithm-ABAQUS back analysis program to solve the shortcomings of the numerical simulation method.Then this paper compiled the genetic algorithm -ABAQUS back analysis program,which was verified by application examples.The comprehensive researches show that: (1).The sensitivity of deformation modulus and poisson's ratio in constant load is greater than the sensitivity of preloading.(2).The final settlement of inversion calculation is close to the actual settlement.The relative error is within 10%.This shows that the parameters of the anti - performance parameters of the ABAQUS- genetic algorithm are effective.In engineering,it is feasible to predict the subsidence by using this method.