A physical model of circle tube with Circumferentially Non-uniform Heated, of which the inner diameter was 16mm and wall thickness was 2mm, was built to numerically investigate the heat transfer of molten salt in the circle tube. The numerical investigation was performed within the range of inlet temperature from 200 to 400 ℃, velocity from 0.6 to 3.0 m/s, heat fluxes from 200 to 400 kW/m². By using the k-ε model, the temperature distribution at outlet section and transfer characteristics were analyzed in detail, as well as the distribution of inner wall temperature. The investigation results show that the temperature of tube wall has large difference at outlet section, and the temperature of molten salt also has a graded distribution. The lower the inlet temperature is, the better the transfer performs. The heat flux has little effect on Nusselt Number. The temperatures at inner wall are non-uniformity on the circumference, increased inlet velocity and decreased heat flux are beneficial to improve the circumferentially non uniform.