In practical engineering, slurry ratio are usually confirmed by experience, which causes slurry properties and formation mismatching, and cannot get ideal grouting effects. In this paper, we will start with the slurry ratio, using single factor analysis to measure permeability coefficient by doing variable head test. On the basis of experiment, we can discuss the change law of slurry permeability in different slurry ratio, and make a further analysis of the matching relationship between slurry and formation. The results showed that: when other components of slurry remain unchanged, slurry permeability decreased along with the cement, fly ash, bentonite growth, and increased along with sand, water reducing agent growth, which could provide an reference for selection of slurry in future engineering.