Taking an 8-story frame structure as an example, using etabs software, the vibration period, interlaminar shear and maximum displacement of different models such as rubber isolation system and sliding isolation system under the interaction between soil and structure can be obtained. the results show that the vibration period of different structures is prolonged, each layer displacement increases, and the sliding isolation system is significantly reduced compared with common structure and rubber isolation system, and the effect of sliding isolation system is better at the class iv site.