Based on the investigation of the actual geological conditions of the project and the slope instability in the first stage of the project, this paper improves the accounting method of the original anti-slide pile reinforcement scheme, and finds out the inadequacies of the original reinforcement scheme of an artificial river in the lower reaches of the Yangtze River.Based on the actual situation of the weak layer in the slope soil layer, the reinforcement scheme of the cement mixing pile is presented.Through the calculation of reinforcement scheme with different replacement rates of 15%, 20% and 30%, we find the safety and stability of the slope of the reinforcement range.According to the calculation results of Geo-slope software, it can be found that the reinforcement scheme under different permutation rate can adjust the reinforcement range to make the safety and stability coefficient of the slope construction period meet the standard requirements.