As one of the key parts of the automobile, suspension can directly determine the ride comfort and driving safety. In order to establish the effective controller of the automobile suspension system, realize the effective control of the suspension system, and thereby improve the stability and safety of the car body, this paper takes the active suspension as the research object, establishes a two-degree of freedom one-fourth suspension model, and a suitable mathematical model is established by force analysis. In addition, based on MATLAB/Simulink, a simulation model was——is established. By selecting the most effective standard of vehicle body acceleration as the control target, a PID controller was built to carry out simulation regulation. Finally, the parameters are adjusted by trial and error method, and the optimal tuning results of PID controller parameters are obtained through multiple simulation.