The Midas Civil & FEA software was used to model and calculate a partial cable-stayed Bridge in service. According to the results of dynamic and static calculation and analysis, the key monitoring sections and measuring points were determined, and the sensor layout was optimized. The data transmission, early warning setting and system integration were overall designed. A complete health monitoring system was formed through the unified management and processing of monitoring data by the intelligent monitoring cloud platform developed for the bridge health monitoring system. Then the operation of the system in the past year was summarized, the problems in the system operation were analyzed and the solutions were put forward. Some monitoring results of the bridge including modal and girder deflection monitoring data were analyzed. The analysis results show that the health monitoring system achieves the design expectations.