In view of the seismic problem of the gas engineering headquarters in Xinjiang Province, the seismic isolation technology was adopted to strengthen the headquarters, and the methods of "pad the column joist" and "clamp the wall beam" were adopted for construction to ensure the safety of its superstructure. Based on the method of time history analysis of seismic isolation and reinforcement, the structure was analyzed by ETABS, an internationally accepted three-dimensional finite element software. On this basis, the damping effect is analyzed. The construction technology and the corresponding key technologies adopted in this project are also introduced. The results show that the isolation effectiveness is relatively remarkable and it can better meet the requirements of the current norms. Therefore, it is feasible to design and construct the base isolation reinforcement.