In response to the influence of pile-soil interaction on the vulnerability of corrugated steel belly plate bridge components, a three-dimensional foundation consolidation model and pile-soil bridge model of a typical corrugated steel belly plate beam bridge were established using ABAQUS finite element software. Fifteen seismic records were selected from the PEER database, and the displacement ductility ratio was used as the damage index to conduct IDA time history analysis on the model. By comparing the vulnerability curves of bridge components under four damage conditions in the pier bottom consolidation model and the pile-soil bridge model, the influence of the pile-soil effect on the vulnerabi-lity of bridge piers and supports was obtained. The calculation results show that the probability of da-mage and failure of bridge piers and bearings in the pile-soil bridge finite element model is higher than that in the foundation consolidation model. Therefore, when conducting vulnerability analysis in practical engineering, it is necessary to consider the influence of pile-soil effect on structural vulnerability.