Although we have made a temporary victory against Coronavirus Dease-19 (Abbreviation COVID-19) in our country, the global epidemic situation is still severe currently, and the number of imported cases is increasing. The weaker tumor patients are the susceptible population of covid-19. Under the epidemic conditions, how to protect tumor patients and reduce infection is a new challenge for medical staffs, patients and their families. In order to provide references for protection and treatment of patients under the epidemic situation, the author combined with own clinical experience, offered the following suggestions on prevention and control for tumor patients during the epidemic period of COVID-19.