Reasonable profit-distribution in each enterprise of reproduction closed-loop supply chain can not only increase the profits of each enterprise and the whole supply chain, but also strengthen the enthusiasm of operation of each enterprise in the supply chain. There isn' t only one factor that can influence the profit distribution of each enterprise in the supply chain. Profit-distribution mode based on the method of Shapley value considers only each enterprise' s contribution to the whole profits of the supply chain , which can' t reflect other factors' role in profit-distribution. Therefore, based on the Shapley value mode, considering the role of capital investment, risk factor and influence on the environment in profit-distribution, profit-distribution mode of comprehensive strategies is constructed. Information entropy is used to set the weight of four profit-distribution strategies. Producers, retailers and reproducers in reproduction closed-loop supply chain are used as examples to distribute profits. This method is proved effective in this paper.