At present, College students' structural unemployment problem in China is outstanding. There are many reasons which cause the problem of independent college students' structural unemployment. With exception of the employment pressure made by the dramatic increase in the number of university graduates, the main causes of independent college students' structural unemployment include the following factors, that is, the unreasonable establishment of major and curriculum, the non-scientific structure of graduates' comprehensive quality, the unrealistic expectation of employment, the lagging school education of entrepreneurship and so on. Therefore, to solve the problem of independent college students' structural unemployment, such problem must be regarded as a complex system to research on. Especially colleges should take scientific measures to control the scale of higher education, adjust specialties and courses of independent colleges reasonably and develop students' entrepreneurship education, so as to solve the problem of independent College Students' structural unemployment.