People focus more on the effective interface between occupation technical college and enterprise, and neglect cooperation and communication between comprehensive university and enterprise. The comprehensive university has the following distinct characteristics: complete discipline classes, various talents, the larger scale of enrollment, the widespread of students. There is more space and potential of cooperation between comprehensive university and enterprises. The author summarizes the main forms of cooperation between Hebei University and enterprises in the recent five years. Main cooperation ways include jointly short-term training, building key laboratory jointly, co-culturing high-level talents, and so on. Theses have achieved mutual benefits in economic and social aspects. But there are some obvious defects, which hinders the effective cooperation between comprehensive university and enterprise..