Modern colleges and universities are trying to cultivate students with strong creative spirit and practical ability, but the disadvantages of traditional educational teaching haven been protruded, which is a heavy barrier to their goals, the research-based teaching offers a new opportunity to implement them. So starting from the differences between traditional and research-based teaching, the teaching difficulties of colleges and universities are analyzed in this article from such aspects as management, teacher's abilities, students and teacher's role, based on which such four aspects and specific measures as changing university governors' thinking, building a trinity teaching mode related to teaching, research and application, leading students to build suitable learning mode, and constructing a new evaluation system are raised.