Since the scientific and technological personnel are playing the decisive role in promoting economic development so that the national and regional governments are paying more and more attention to them. In recent years, Handan has taken some measures to promote scientific and technological personnel gathering in Handan and has achieved some success, but some problems still exist in the process of gathering. This paper is based on the perspective of the Central Plains Economic Zone, and first makes a review of researches on the issue of technology professionals gathering. After analyzing current situation and problems of scientific and technological personnel in Handan, it explores and integrates effective paths to optimize scientific and technological personnel gathering in Handan, in order to achieve its goal to be an important center city of the central zone.