Abstract: Supply chain business expanding globally and the lean philosophy developing lead to enterprises increasing degree of dependence on suppliers gradually. However, suppliers influenced by real risk factors are often unreliable. In the event of supply disruptions, it will cause huge losses to the enterprise. Supplier evaluation is an effective measure to prevent disruption risks. For this purpose, a supplier evaluation index system based on supply disruption risk prevention is established and an evaluation model used the entropy method and fuzzy comprehensive evaluation method is constructed and then the comprehensive strength of each supplier is calculated through the example. These provide theoretical basis for enterprises to select qualified supplier.