‘Reproduction in Domestic Animal' is a practical and basic specialty course for major of Animal Science at college, and is also the basis of reproductive physiology and reproductive technology for Livestock Production at the latter. There is a direct relation between ‘Reproduction in Domestic Animal' and specialty courses for major of Animal Science. In this paper, the advantages of case-teaching and construction for case library of ‘Reproduction in Domestic Animal' are described. Meanwhile, the applications and problems of heuristic case-teaching on ‘Animal Reproduction Science' are introduced. At last, it is recommended that case-teaching should be combined with specific conditions and should be improved continually at the process of teaching. In addition, case-teaching should be combined with multimedia teaching, and a suitable case-teaching model for ‘Reproduction in Domestic Animal' should be worked out.