The concept of Flipped Classroom has been widely researched and used in all levels of education. HRM course is the main course of management professional in open and distance education. It will improve the ability of the learner when apply Flipped Classroom in the teaching of HRM course. The author describes the significance of flipped classroom, the characteristics learners and HRM Course in open and distance education, discusses the teaching mode of HRM course in distance open education from the view of Flipped Classroom, analyzes the problems in the implementation of the mode, then proposes strategies such as enriching teaching resources, promoting to switch role of teachers, improving the mechanism of learning evaluation.