this paper explores the internal relationship between the occupational high altitude and the work performance based on the data from the questionnaire survey, and what role of self-efficacy plays in this relationship. The results are: The negative influence of the levels of the plateau and the central altitude on the work performance is significant;the moderating effect of self-efficacy on the relationship between occupational plateau and job performance is significant. From the management of enterprises and R & D staff from double perspective, this paper proposes the optimization of organizational design, strengthening and employee communication, staff care and improving self-efficacy to slow career plateau arrival and to improve the work performance.