This paper, from the current situation of regional economic development in Hebei Province, selected the range, ratio, standard deviation, variation coefficient, Theil coefficient and Gene coefficient to measure the 6 economic indicators of differences, analyzed the changes of the economic differences in Hebei Province.The result show that the economic differences in Hebei province has a growing trend.The paper puts forward countermeasures and suggestions to promote the coordinated development of regional economy in Hebei province from the aspects of improving macro view control, Strengthening cooperation with Beijing and Tianjin, adjusting industrial structure and introducing talents.