Objective: Improve the satisfaction of patients through the improvement of nursing process with the methods of comfortable nursing. Methods: Analyze 100 cases of surgery, in which comfortable nursing was used during the period of general anesthesia, sum up experiences, and make the corresponding nursing measure. Results: Comfortable nursing can set corresponding action to solve the patients' fear of aching and the suspicion after the operation, which can make the patients feel comfortable in the aspect of physiology, psychology, society and spirit. It can remove or reduce the discomfort of the patients, which not only ensures the success of the surgery, but also improves the safety of the surgery and reduces the complicating diseases. The patients can have surgery in ease, so they are at an optimal condition during the operation. Conclusion: It can improve the nursing quality of operation room, make the nursing accommodation comfortable, and promote the development of holistic nursing, paying attention to patients' feeling and satisfaction by mental condition, temperature and comfortable nursing of operation room during the surgery.