A phenomenon of separation from college students' practical life exists in current practical teaching of college ideological and political theoretical course. It requires ideological and political educators to make clear the concept of practical teaching of college ideological and political theoretical course; to break through from the four aspects of education reform ideology, implementation mode, connotation construction and integration mechanism; and to polish with the strategy of five combinations and construct "relevant to life" mode in practical teaching of college ideological and political theoretical course. Practice has proved that the mode can effectively promote the effectiveness of ideological and political education and enhance college students' sense of gain.