The personnel training in Colleges and universities in China is confronted with multiple contradictions between supply and demand, which are mainly manifested in the structural contradictions between the types and qualities of professional talents and the types and qualities of social talents needed by colleges and universities. Starting from the main contradiction, the key to talent training in Colleges and universities is to reform itself from the supply-front. Colleges and universities should expand the number of enrollment, adjust specialities and curriculum, improve the level of teachers, optimize teaching resources, strengthen practice, and enhance students' awareness of self growth.