As a social ideological trend of western philosophy, Marxism can be rooted and develop in traditional Chinese culture, which is not accidental cultural events and historical events. They must agree with each other. At present, in the new historical environment, exploring the cultural relevance between the sinicization of Marxism and traditional Chinese culture will provide the most reliable theoretical guarantee for the development of socialism with Chinese characteristics. By analyzing the similarities and mutual influence between Marxism and traditional Chinese culture, this paper will comb and discuss the dialectical relationship between the sinicization of Marxism and traditional Chinese culture.