Objective:To explore the moderating effect of trusting others on the relationship between family environment and interaction anxiousness. Methods:257 college students were investigated by FES-CV, IAS and Faith in People Scale. Results:①Cohesion, Expressiveness was negative correlation with Intellectual-Cultural Orientation and faith in others and Interaction anxiousness; Interaction anxi-ousness was related with Active-recreational Orientation.②Faith in others moderated the relationship between Conflict and Interaction anxiousness of college students. Conclusion:Poor family environment factors are Contribute to college students' interaction anxiousness,but the medium levels of faith in others could reduce the level of interaction anxiousness of college students.