The rapid development and extensive application of new media technology nowadays have provided new technical support and a broad stage for university entrepreneurship education and practice. Based on the theoretical research and working practice of the authors, this paper first points out the problems of new media in universities, especially in the fields of the entrepreneurship education and practice courses, professional teachers, platform construction, and further popularization. Then it puts forward the application strategies of new media, including creating the atmosphere of entrepreneurship education and practice in universities, training two entrepreneurial education teams of both teachers and students, creating an innovation service platform, and adopting the practice mode of "new media + entrepreneurship".