With the continuous development of the construction industry, modern architects need to have strong comprehensive abilities of design, cooperation and innovation. The teaching exploration of architectural design course based on cooperative game is aimed at cultivating architects with comprehensive ability. Through implanting cooperation consciousness throughout the course, setting the relevant mandatory agreement, this course guides the students to take the initiative to establish the correct cooperation to complete the task of learning at all levels, enhancing the students' comprehensive ability in cooperation. A real-time evaluation system is established to evaluate the learning results. The research shows that the teaching model can effectively improve students' academic performance, cultivate their comprehensive quality and meet the requirements of engineering talent training.