The application of Internet provides a new engine for social progress and economic development, and at the same time it promotes the reform and development of innovative entrepreneurship education in colleges and universities. The innovation and entrepreneurship education in colleges and universities are undoubtedly a part of “mass entrepreneurship and innovation”. University innovation and entrepreneurship education are bound to have a close relationship with “Internet Plus”. Based on the “Internet Plus”, it is necessary to integrate innovation and entrepreneurship education of college and university students with Internet achievements and give full play to the optimization and inheritance role of the Internet in production factors. Building a mutual selection mechanism for teachers and students is also important to improve the professional level of innovation and entrepreneurship, and it can also promote the leap-forward development of innovation and entrepreneurship education in colleges and universities.