The paper analyzes the contradiction of chemical professional foundation course between the higher vocational colleges students' learning and the teachers' teaching, combining with the actual case. It aims at improving the teaching effect by adopting a series of measures:using information technology opportunely, more fun in class, introduce real cases to increase the practical ability of students, cooperate with industry enterprises around the typical task teaching and textbook writing, highlight the practical application of experimental course, set up online network teaching platform, etc.In the end, summary and outlook are discussed.