Practical teaching to the course of Safety System Engineering was designed systematically under the guidance of New Engineering. Every knowledge point was connected closely with practical teaching methods on the basis of knowledge points and students' cognitive states. Systematic practical teaching emphasized matching between teaching content and the practice teaching methods. The systematic practice teaching system and the classroom teaching synchronously was carried on. Each student learns knowledge point and at the same time to complete its corresponding practice training. At the end of the course, students' sense of acquisition by course learning, their practical ability and engineering literacy have been greatly improved.